A2M and SuperShot PRP Therapy in Atlanta
Experience the next evolution in regenerative medicine. SuperShot is one form of PRP therapy in Atlanta at Paragon, and it goes further than standard platelet therapy by capturing valuable healing components that conventional processing throws away, including extracellular vesicles (EVs) and Alpha-2-Macroglobulin (A2M). This advanced protocol retains more of these components than standard PRP, giving damaged tissue more to work with. Each treatment is ultrasound guided for precision.
Amplified Healing.
Accelerated Recovery.
At Paragon Sports Medicine, we understand that optimal healing requires more than just platelets – it demands the full spectrum of your body's regenerative biology. SuperShot PRP represents a high-concentration platelet therapy, utilizing a patented three-phase aqueous centrifugation system to capture low-density biomolecules that standard PRP processing discards.
While conventional PRP concentrates only platelets and growth factors, SuperShot additionally isolates extracellular vesicles containing critical proteins and microRNAs, plus Alpha-2-Macroglobulin, a powerful antiprotease that inhibits cartilage breakdown. In laboratory testing supplied by the manufacturer, SuperShot processing recovered about 1.18 trillion more extracellular vesicles per millilitre than standard PRP from the same blood draw, an increase of roughly 75%. That testing measured particle counts only. Published head-to-head outcome data comparing the two preparations remains limited.
The Science Behind
SuperShot PRP
SuperShot PRP takes regenerative medicine to the next level by delivering significantly higher concentrations of the essential growth factors your body needs to heal. This enhanced formulation includes:
Ultra-High Platelet Concentration
Delivers 5-7 billion platelets with PDGF, VEGF, IGF-1, TGF-β, and FGF to reduce inflammation, stimulate collagen production, and accelerate tissue repair.
75% More Extracellular Vesicles
Containing proteins and microRNAs essential for tissue regeneration and healing.
Retains Alpha-2-Macroglobulin
Concentrates this large antiprotease protein that inhibits cartilage breakdown and reduces joint degeneration – typically lost in standard PRP processing.
Patented three-Phase Processing
Uses a specialized aqueous centrifugation system requiring only one additional minute to capture low-density biomolecules while maintaining complete autologous purity.
Accelerated Healing Timeline
Higher growth factor concentrations can lead to faster symptom improvement and more complete tissue restoration.
For Complex Cases
For athletes wanting a more concentrated regenerative option, or individuals with degenerative conditions, SuperShot PRP retains components that standard processing discards. Capturing extracellular vesicles and A2M is intended to give damaged tissue more of the material it uses to repair. This protocol is used in joint degeneration, chronic tendon injuries, and cases where a more complete preparation is wanted.
SuperShot PRP is ideally suited for:
Osteoarthritis & joint degeneration
Knee, hip, or shoulder arthritis where A2M's antiprotease properties help inhibit cartilage breakdown and the enhanced EV content supports tissue regeneration.
Severe tendon/ligament injuries
Tennis elbow, Achilles tendinopathy, rotator cuff tears, ligament sprains, or muscle strains where extracellular vesicles accelerate healing and tissue restoration.
Elite athletic performance & recovery
Athletes who want a more complete preparation, retaining components that standard PRP processing discards.
Your Journey to
Advanced Recovery
Blood Draw
A blood sample is collected in the Paragon office using the same volume as standard PRP procedures (compatible with EmCyte PurePRP systems).
Advanced PRP Preparation
Your blood undergoes conventional dual-spin centrifugation to concentrate platelets (5-7 billion) while separating platelet-poor plasma (PPP) for the next step.
SuperShot Enhancement
The PPP undergoes an additional one-minute spin with patented centrifugation solution, isolating low-density extracellular vesicles and A2M that standard processing discards.
Ultrasound-Guided Injection
Using real-time musculoskeletal ultrasound, Dr. Garten precisely injects the complete SuperShot PRP formulation directly into damaged tissue for maximum therapeutic delivery.
Recovery Protocol
You'll receive a personalized activity plan with instructions to avoid NSAIDs for one week before and 4-6 weeks after treatment, plus follow-up scheduling optimized for SuperShot healing timelines.
Precision Expertise. Proven Excellence.
SuperShot PRP requires advanced processing protocols and technical expertise. Success depends on critical factors that set Paragon apart:
With over two decades of experience in regenerative medicine, Dr. Garten brings elite sports medicine expertise to the Atlanta area. He performs every SuperShot injection under real-time ultrasound guidance.
The SuperShot Advantage
More Complete Healing Biology
Captures extracellular vesicles and Alpha-2-Macroglobulin that standard PRP processing discards, recovering about 75% more extracellular vesicles from the same blood draw in the manufacturer's laboratory testing.
Sustained Long-Term Outcomes
When standard treatments haven't provided adequate results.
Enhanced Cartilage Protection
Higher A2M concentration acts as a broad antiprotease, inhibiting enzymes that break down cartilage – particularly beneficial for osteoarthritis and joint degeneration.
Accelerated Tissue Regeneration
For elite athletes and high performers, SuperShot PRP provides maximum regenerative capacity to ensure the strongest possible tissue repair and minimize reinjury risk.
More Complete Preparation
Our SuperShot technique uses a higher platelet concentration and retains components that standard processing discards.
SuperShot PRP Therapy:
Your Questions, Answered
If your pain is centered in the knee, see our dedicated page on PRP knee injections in Atlanta.
Schedule a
consultation
We treat injuries and we work on what caused them. Whether you're an athlete returning to peak form or an active individual who wants to move better, our programs are built on clinical assessment, testing, and published evidence.
Our multidisciplinary approach blends diagnostics, rehabilitation, strength training, and recovery to support your body through every stage of its performance journey. Progress here isn't accidental – it's intentional.
Adipose and bone marrow derived cell therapies are not FDA approved for the treatment of any orthopedic condition.
Schedule a
consultation
We treat injuries and we work on what caused them. Whether you're an athlete returning to peak form or an active individual who wants to move better, our programs are built on clinical assessment, testing, and published evidence.
Our multidisciplinary approach blends diagnostics, rehabilitation, strength training, and recovery to support your body through every stage of its performance journey. Progress here isn't accidental – it's intentional.
Adipose and bone marrow derived cell therapies are not FDA approved for the treatment of any orthopedic condition.